The promise of a regimen that offers hours of continuous focus and concentration with the ability to heighten creativity began to circulate in Silicone Valley back in 2010. By 2013 microdosing was all the rave within these circles and soon became a popular mainstream topic that is now followed by millions worldwide, thanks in part to the teachings of LSD researcher, Dr James Fadiman. Since, the topic has been covered by many mainstream outlets, including GQ and Rolling Stone.

Before you begin a microdosing regimen its a good idea to research the topic to the best of your ability. On this page we provide an overview of everything you need to know before you get started, if that is what you choose to do. Make sure you read this overview fully and then move on to one of our free microdosing guides to get started.


Introducing sub-perceptual doses of psychedelics, such as LSDDMT or Psilocybin Mushrooms into your weekly routine with the purpose of achieving higher levels of creativity, improved rational skills and increased focus and energy is known as the act of Microdosing. To put it simply, microdosing is taking psychedelic substances in such minute amounts that they dont produce a full on trip, but rather produc subtle effects. As The New York Times comments, the effects should be “too small to inspire Technicolor hallucinations, but large enough to enhance a sense of mental flow.”

Long-term drug researcher and psychologist Dr James Fadiman suggests 1/10th to 1/20th of your usual dose of a substance, on average this equates to 10 to 25 micrograms of LSD or 0.1 to 0.4g of Psilocybin – every fourth day. We cover Dr Fadimans protocol later on in this guide.

Our goal is to provide well-researched knowledge regarding the science, benefits, protocols, and effects of microdosing for professional and emotional growth. However, remember that these substances, although widely covered by mainstream media, are still illegal in most countries. We do not encourage the use of illegal drugs, we are simply here to offer knowledge in the hope of preventing harm and further educating those who choose to do it regardless of what the law says.



Spirit Molecule - Dr James Fadiman 

Dr James Fadiman, a longtime LSD researcher who published The Psychedelic Explorer’s Guide back in 2011 was responding to questions from psychonauts requesting help with their microdosing regimens up until a few years ago. After helping thousands worldwide, he published his microdosing protocol, which was based on his many email reports from users he had helped. This protocol soon became the microdosing standard. Now Fadiman is working with fellow researcher Sophia Korb as they embark on the largest nonclinical microdosing study to date (59 countries and over 400 participants).

We will go into more detail on the protocol later on.


“What microdosing seems to do is rebalance people. Here’s a generalization, which is how I’ve come to this conclusion: A number of people, by the time they’ve finished a month, say, “I’m sleeping better, I’m eating more healthy food, I’ve returned to yoga and I’m doing meditation.” They’ve improved their relationship to their body ― or their body has improved their relationship to them…What seems to happen with microdosing is that you’re more attuned to your own real needs.”

~ Dr. James Fadiman, Ph.D.



Fadiman claims that microdosing can help with various problems, including depression, anxiety, ADHD, shuttering and period cramps. It is also shown that microdosing can greatly improve mood, focus, increase energy and creativity levels and help with physiological enhancements.

With some of the facts available to us through recent research and user reports, scepticism should be applied, claims Dr Matthew Johnson from the John Hopkins University, who suggests these benefits are due to the placebo effect; “Expecting to have a wonderful day is a good recipe for having a wonderful day.”

It should also be noted that LSD is still a controlled substance in many western countries, therefore no official scientific research or experimentation has been carried out in recent years, meaning most of the evidence available to us where LSD is concerned is anecdotal.

Some benefits of microdosing according to a study published by The Harm Reduction Journal:

Cognitive Benefits
When microdosing, user experience heightened mental clarity, better memory recall, and an improvement in problem-solving ability.

Improved Mood
Peacefulness, overall well-being, calmness, happiness, and a reduction in the symptoms of depression. Also includes more emotional connection, a general sense of optimism, and an improved outlook on life.

Physiological Enhancement
Includes enhanced visual acuity, cardio endurance, reduction of migraines and headaches, and higher quality of sleep.

Improved Focus
Covers skill sets like the ability to focus or concentrate, and enhanced self-awareness.

Aside from a general sense of improved creativity, this also includes behaviours such as being more open, enhanced curiosity, ability to shift perspectives, and divergent thinking.

This applies to such behaviours as ambition, self-motivation, self-confidence, and a sense of agency. It also relates to improved mental health, including increased introspection, the practice of meditation, and other aspects behaviours tied to self-care.

Improved Energy
In this case, “energy” refers to things like mental stimulation, wakefulness, and alertness.

Social Benefits
Outside of more engagement with others, this category also includes more empathy, a greater sense of connection, and more extroversion.

Reduced Anxiety
This applies to a reduction in both general and social anxiety.


“Someone might be expecting a kind of sparkly day, just a really productive day at work—and next thing you know, they’re grasping hold to their office chair wondering why the world is dissolving.”

~ Dr. Matthew Johnson, Ph.D. Johns Hopkins Hospital

The most obvious risk when it comes to microdosing is legality issues. Due to increased scientific research showing the potential benefits of Psilocybin Mushrooms, there is now more leniency when it comes to the law, however, it is still prohibited in many western countries. LSD is still a controlled substance in many countries, therefore no official scientific research or experimentation has been carried out in recent years. It is therefore vital that you understand the laws in your country surrounding these magical substances before you embark on your journey.

Fadiman recently reported that from the information he has collected from his long-term test subjects indicates that those who were mainly using psychedelics (microdosing) to treat anxiety found it actually increased their anxiety! This was not, however, the case with those who entered the study with the intention of decreasing both anxiety and depression, which did in fact find microdosing helpful in relieving their symptoms.

Other recent research may indicate that long-term microdosing of psychedelics could potentially cause heart problems. It is therefore important to do your research properly if you suffer from heart problems or anxiety. If you suffer or have a family history of psychosis should avoid using psychedelics, whether it be a microdose or macrodose.

Some people find Psilocybin Mushrooms upsetting on their stomach, some also report abdominal pain and cramping when microdosing with psilocybin. Always start with the lowest dose and work your way up to eliminate the risk of facing any issues if you have not experimented with mushrooms before.


With all the compelling reports and scientific research in recent times about the benefits if microdosing, the risks cannot be ignored:
  • Most psychedelics are still illegal in western countries, meaning possession could land you in prison
  • If buying psychedelics off the dark web or off the street, it is difficult to know what you’re taking, in terms of purity, potency and safety
  • Not doing your research before you microdose could mean you put yourself and others at risk, or both. Accidentally having a full-blown trip while at work is not a pleasant experience
  • If you suffer from or have a family history of Panic attacks, Psychosis or schizophrenia should avoid using psychedelics
  • Tolerance, cross-tolerance or adverse effects with other medications you are taking

In addition, specific psychedelics have their own hazards:


  1. Flashbacks – up to 50% of users report at least one flashback
  2. Hallucinogen-Persisting Perception Disorder (HPPD)
  3. Valvular heart disease

Psilocybin Magic Mushrooms

  1. Extreme muscle weakness
  2. Loss of bodily functions
  3. Out of body experiences
  4. Alien contact


The most popular substances used by microdosers are LSD and Psilocybin Mushrooms. Both offer slightly different effects but are generally very similar in their overall effect. The substance you choose to microdose with is very personal and will generally depend on a couple of things.



Before picking the substance to microdose with, decide what you want to achieve from your microdosing protocol, ask yourself some of these questions:

  1. Are you looking for more focus or more creativity?
  2. Do you want to be more logically orientated or more attuned to your emotions?
  3. Are you looking to connect more easily with other people and open the door to exercising more empathy or is your approach more about ignoring what others think and getting the work done?

Neither one is better or worse and your ultimate goal dictates which substance best suits your needs.


Psilocybin is an organic compound, LSD is synthetic, each will affect your body differently, for example:

  • Psilocybin can produce more creativity, openness, empathy and less concentrated focus, analytical thinking and logic.
  • LSD works quite the opposite, it opens up the brain to more logical ways of thinking, more focus and less empathy or openness.

We have a pretty good idea how larger doses of these substances can affect people, but with microdoses it is harder to predict how each person will be affected. The best way is to experiment and see what works for you, be your own scientist!



Our guides cover the basics of everything you need to know to start Microdosing, including topics covering the History of Microdosing, the Science & Research backing it, Benefits, Risks and How to Guides to get you started on your journey. If you want to dive deeper, pre-register now for our Microdosing Course and be one of the first to take it for a spin with an exclusive 15% discount on launch

Spirit Molecule - LSD Microdosing Guide


What is LSD: It is a synthetic drug manufactured from lysergic acid, a fungus found growing on rye grains. It is most commonly found in Liquid form or on Paper Tabs.

What it feels like to Microdose LSD: Most users report an increase in energy, focus and overall well-being which can be best described as “the perfect day”. Microdosing LSD has shown to help user beat addictions such as smoking, drinking and binge eating, as well as harder addictions, including heroin dependancy. It also tends to bring out the creativity hidden deep within for most users.

Spirit Molecule - Psilocybin Microdosing Guide


What is Psilocybin: It is the psychoactive compound found in Magic Mushrooms. This is the most popular substance used for Microdosing and can be taken in Powder form, brewed in a tea or simply eaten as as (mushrooms).

What it feels like to Microdose Psilocybin: An increase in focus and energy is noticed within 45 minutes of ingesting a Microdose. Many users report increased empathy, a love for life and nature, a clear head and the ability to make rational decisions or carry out tasks more efficiently. Psilocybin can help kick may types of addiction, including smoking, drinking and other hard addictions, many users find it allows them to gradually wean themselves off anti-depressants after starting a Microdosing regimen.

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In this first step, you will decide on your protocol of choice. Your protocol will outline how often you microdose and what you do in between doses. The most common microdosing protocol is the Fadiman Protocol laid out by Dr. James Fadiman, which we touched upon earlier. This protocol was produced based on microdosing research he has been working on since 2012.

The Fadiman Protocol is great a great place to start, especially for beginners. Once you have experimented with microdosing for a few weeks you can begin to adjust the protocol to suit you and your needs. Everyone is different in how they handle the microdosing process, therefore its important for you to be present and observe yourself during this process. Only you know what works for you, we suggest you begin with the Fadiman Protocol and adjust as you see fit once you get the hang of things.

This protocol can be used for microdosing both Psilocybin and LSD and includes the following steps


Spirit Molecule Microdosing Guide - 4 Steps to Microdosing with Psilocybin & LSD


A microdose needs to be sub-perceptual, that means the dose should be roughly 1/10th of a standard dose, this can vary from person to person but it is typically in that range and only differs by a small amount. Typically, a standard dose of psilocybin mushrooms is approximately 3.5 grams of dried mushrooms. A microdose therefore, is around 0.2 to 0.3 grams.



You should make it a habit to journal throughout the day when you begin microdosing. Take notes on any changes you see in your mood, perception, mental state, or feelings that arise on your microdosing day and the day after.



You should calibrate your dose slowly to adjust to your needs. Everyone’s dose will be different and there are many factors that influence this, including body composition, mental state, and prior experience with psychedelics. When calibrating, make incremental changes in the amount you take. This will help to optimize the experience.



By following the Fadiman Protocol you will be dosing on day 1, resting for 2 days and then dosing again on 4 and so on. So for example, if your first dose was on Monday, you don’t dose again until Thursday. We recommend you microdose for 8 weeks and taking a break to evaluate the outcome. You should take intermittent breaks from microdosing in order to allow your body to adjust and not build a tolerance.



Once you have familiarized yourself with the Fadiman protocol you may choose to experiment with different versions, or creating your own unique protocol, remember, nothing is written in stone here.



This is the common Fadiman protocol we covered above.

Week 1: Mon/Thu/Sun
Week 2: Wed/Sat
Week 3: Tue/Fri
Week 4: Mon/Thu/Sun

Dosage: Read our Microdosing Guides (LSD or Psilocybin) to dive deeper in to how to dose correctly on this protocol).


This modified protocol aims at those who are looking to microdose for improvements at work. Weekends are left free for recovery and to solve any tolerance issues that may build up during the week.

Week 1: Mon/Tue/Wed/Thu/Fri
Week 2: Mon/Tue/Wed/Thu/Fri
Week 3: Mon/Tue/Wed/Thu/Fri
Week 4: Mon/Tue/Wed/Thu/Fri

Dosage: Read our Microdosing Guides (LSD or Psilocybin) to dive deeper in to how to dose correctly on this protocol).


This protocol is a more balanced approach, doses are taken every other day with a day in between for resting.

Week 1: Mon/Wed/Fri/Sun
Week 2: Tue/Thu/Sat
Week 3: Mon/Wed/Fri/Sun
Week 4: Tue/Thu/Sat

Dosage: Read our Microdosing Guides (LSD or Psilocybin) to dive deeper in to how to dose correctly on this protocol).



When microdosing its important to keep a journal and make notes on your state of being, below are 7 points to consider when journaling on a microdose. Your journaling habit should ideally extend over to those days where you don’t microdose too.



Analyze the thoughts you have throughout the day. Are they different in any way? Are they more frequent or less? Do the thoughts seem to rush through your mind or come one at a time? Is your mind cluttered or more clear?


Are you more creative? Do you seem to enjoy art more or the act of creating things? Do you see the finer detail in everyday objects? Are you getting more ideas than you do normally? Do you find solutions to problems more easily?


Do your feelings take on any different qualities than before? Are there more or fewer feelings experienced than usual? How quickly do you process them before reaching a resolution and moving on? Is sex better, or a different quality?


How are you expressing your thoughts and feelings? Are there any changes in the pacing, tone, or nature of your speech? What about your facial expressions? Do you smile more or less? What frequency do you agree or disagree with someone in conversation? Do you talk differently with your coworkers, spouse, friends and family? The barista at the local coffee shop?


Take a look at how aware (or not aware) you are of your body. Now zoom in on the body by closing your eyes and taking a few deep breaths. Slow your mind and place your full attention on any sensations in your body. Do you notice anything?


Are you more positive or negative? More optimistic or pessimistic? More or less sceptical? More fearful and guarded, or open to possibilities Feelings of oneness, universality, truth, connectedness, love, or peace are also in this area.



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Golden Teacher

Spirit Jar XL

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After the blanket ban on psychedelics back in the 1970’s all psychedelic research came to a halt. Only in recent years have we began to see a surge in the number of scientists showing an interest in these substances. The findings from the research carried out in recent years is very positive and promising, although most of the research is done based on higher doses of these substances and not microdosing itself, though this is changing rapidly with more scientists showing an interest in recent times.

In a controlled clinical study, Psilocybin was found to clear “resistant depression” after just 2 sessions with a psychedelic therapist. This study was conducted using 12 participants over a 3 week period, where 5 were found to be clear of their symptoms 3 months later.

Two studies in 2016 — one with 29 participants, the other with 51 — investigated the effects of therapeutically-administered psilocybin on cancer patients, giving them the drug in a controlled environment. The studies, which were released simultaneously in The Journal of Psychopharmacology, showed about 80% of participants reported a “clinically significant” reduction in anxiety and depression months after just a single dose.

UK-led study in which the brains of 20 participants while on LSD were scanned gave some insight into why your post-LSD brain might be happier, showing “reduced blood flow” within “some important brain networks, such as the neuronal networks that normally fire together when the brain is at rest.”

There are no easy answers on this one. It’s tempting to succumb to the hype: creativity, productivity, more emotional empathy and a better mood with minimal side effects all sound massively appealing. Nevertheless, given the lack of long term studies, it still involves playing roulette with your brain chemistry.

Ultimately, you’re the only person who can decide if microdosing is for you.

Organizations like MAPSThe Beckley FoundationHeffter Research InstituteJohns HopkinsUsona and others are paving the way for a new paradigm in mental health. Below are a few of the key studies which demonstrate the benefits of microdosing psychedelics:


Richard A. Friedman, professor of clinical psychiatry and director of the psychopharmacology clinic at Weill Cornell Medical College, thinks microdosers should hold out for more-conclusive science.

“The problem is that the large-dose therapeutic studies that have been done so far — the NYU and Johns Hopkins ones in particular — are flawed, I think, so we don’t really know how safe or effective it is. For example, niacin, which was used in the NYU study as a placebo, doesn’t really have a psychedelic effect, so my objection is that it’s just a weak study. And then there’s the sample: Who raises their hand and does a hallucinogen? Those people might be more psychologically hardy and drawn to novel experiences. With microdosing, if you’re going to posit x or y about it, then go study it and get good data. Otherwise, everybody thinks it’s perfectly safe, but there are people who are going to do it who are at risk for various psychiatric problems like schizophrenia, bipolar disorder, and severe depression, or who have a genetic loading for psychotic disorders and could unleash a latent illness. That’s who I worry about. Claims that are made based on anecdotes and individual stories are interesting but not conclusive, and they need to be subjected to the same rigorous study as any drug company that wants to sell a drug on the market.”


Read the latest articles about Microdosing on our blog. If you are interested in contributing to our blog please contact us, we are always looking to expand our circle and welcome offers of partnership.

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Microdosing Protocol Course

Our upcoming course will teach you everything you need to know about Microdosing Psychedelics safely for optimal spiritual and personal growth

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Our upcoming course will teach you everything you need to know about cultivating Magic and Exotic mushrooms at home