Drugs (if you can even call them that) that have psychedelic reactions when taken can profoundly experience the wat we see the world. This new research, published in Human Brain Mapping, has examined the brain effects of psilocybin, using data from the brain scans of volunteers injected with the compound.
“What we have done in this research is begin to identify the biological basis of the reported mind expansion associated with psychedelic drugs,” said Dr Robin Carhart-Harris from the Department of Medicine, Imperial College London. “I was fascinated to see similarities between the pattern of brain activity in a psychedelic state and the pattern of brain activity during dream sleep, especially as both involve the primitive areas of the brain linked to emotions and memory. People often describe taking psilocybin as producing a dream-like state and our findings have, for the first time, provided a physical representation for the experience in the brain.”
Lead author Dr Enzo Tagliazucchi from Goethe University, Germany said: “A good way to understand how the brain works is to perturb the system in a marked and novel way. Psychedelic drugs do precisely this and so are powerful tools for exploring what happens in the brain when consciousness is profoundly altered. It is the first time we have used these methods to look at brain imaging data and it has given some fascinating insight into how psychedelic drugs expand the mind. It really provides a window through which to study the doors of perception.”
“Learning about the mechanisms that underlie what happens under the influence of psychedelic drugs can also help to understand their possible uses. We are currently studying the effect of LSD on creative thinking and we will also be looking at the possibility that psilocybin may help alleviate symptoms of depression by allowing patients to change their rigidly pessimistic patterns of thinking. Psychedelics were used for therapeutic purposes in the 1950s and 1960s but now we are finally beginning to understand their action in the brain and how this can inform how to put them to good use,” he added.